When cancer spreads from its original site to other parts of the body, it’s known as metastatic cancer. This article aims to provide information about cancer metastasis, the common areas of metastasis based on the origin of the cancer, observable signs and symptoms, and how families can support their loved ones as the cancer progresses.

What is Metastatic Cancer?

Metastatic cancer is when cancer cells spread from the point of origin to distant areas in the body. Unlike normal cells, cancer cells can grow outside of their original location. Metastatic tumors can grow into nearby tissue, travel through the bloodstream, or move through the lymph system.

Types of Cancer Prone to Metastasis

Virtually all types of cancers can potentially metastasize, but certain types are more likely to spread. Some common types include:

  1. Breast cancer
  2. Prostate cancer
  3. Lung cancer
  4. Kidney cancer
  5. Thyroid cancer
  6. Colon cancer
  7. Pancreatic cancer
  8. Bone cancer
  9. Liver cancer

Common Sites of Metastatic Cancer

The most common areas where cancer tends to spread:

  1. Bones
  2. Liver
  3. Lungs
  4. Brain
  5. Lymph nodes

Common Sites of Cancer Metastasis Table

Cancer OriginCommon Sites of Metastasis
BoneLiver, Lungs, Peritoneum
BrainVarious parts of brain
BreastLungs, Liver, Bones, Brain
ColorectalLiver, Lungs, Peritoneum
KidneyLungs, Bones, Liver, Brain
LaryngealLungs, Bone, Liver, Neck, Trachea
LiverLungs, Bones, Lymph Nodes
LungBones, Lymph Nodes, Lungs, Liver
OvaryPeritoneum, Liver, Lungs
PancreasLiver, Lungs, Peritoneum
Parotid GlandLungs, Lymph Nodes, Nerves in the Face and Neck
ProstateBones, Lymph Nodes, Lungs, Liver
StomachLiver, Lungs, Peritoneum
ThyroidLungs, Bones, Lymph Nodes
All types of cancers can potentially metastasize, but certain types are more likely to spread. This table considers the most common areas where cancer tends to spread based on where starting location (origin) of the cancer.

Observable Signs and Symptoms of Metastasis

Signs of metastasis can vary depending on the affected area. Some common observable signs include:

  • Persistent pain: Feeling pain that does not disappear or worsens over time. This can happen if the cancer cells damage the bones, nerves, or organs.
  • Fractures or bone weakness: Bones that break easily or feel weak can happen if cancer cells weaken the bones or cause them to lose calcium.
  • Difficulty breathing: If the cancer cells spread to the lungs or chest area, trouble breathing or coughing can occur frequently.
  • Frequent headaches or neurological symptoms: If the cancer cells spread to the brain or spinal cord, you may experience headaches, dizziness, or changes in how you think or act.
  • Swelling or lumps in lymph nodes: Seeing swelling or lumps under the skin, especially near the armpits, neck, or groin. This can happen if the cancer cells spread to the lymph nodes, which are small glands that help fight infections.
  • Jaundice (yellowing of skin or eyes) if the liver is affected: Skin or eyes that look yellow. This can happen if the cancer cells spread to the liver, which helps digest food and remove toxins from the body.

Supporting Your Loved One as Cancer Progresses

As cancer progresses, your support becomes crucial. Here are some ways to help your loved one:

Emotional Support

Sometimes, your loved one may want to talk about how they feel or what they are afraid of. You can be a good listener and tell them you are there for them. You can also say things that make them feel hopeful and loved, such as “I’m proud of you” or “You are not alone.”

Physical Comfort

Your loved one may have pain or discomfort because of the cancer or the treatments. You can help them by giving them their medicines, making them comfortable in bed, or massaging their hands or feet. You can also ask them what they need or want to feel better.

Practical Help

Your loved one may be unable to do things they used to, such as cooking, cleaning, or driving. You can help them by doing these things for them or asking someone else to help. You can also help them get to their doctor appointments and keep track of their medicines and test results.

Communication

Your loved one may have things they want to say or do before they die. You can help them by having honest and respectful conversations with them. You can ask them about their wishes and preferences, such as where they want to die, who they want to see, or what they want to do. You can also help them write a will, a letter, or a video message for their loved ones.

Quality Time

Your loved one may want to spend time with you and do things they enjoy. You can help them by being with them and doing activities that make them happy, such as watching a movie, listening to music, or playing a game. You can also share memories, stories, or jokes with them and make them laugh.

Care Coordination

Your loved one may need different care from various people, such as doctors, nurses, or hospice workers. You can help them by working with these people and ensuring they get the best care possible. You can also ask questions, share information, and express your concerns or opinions.

Conclusion

Understanding metastatic cancer and its signs is crucial for patients, caregivers, and nurses. By knowing the common sites of metastasis, observing symptoms, and providing compassionate support, families can enhance the quality of life for their loved ones on their end-of-life journey.

Resources

Clinical Landscape of Cancer Metastases

Metastasis (Metastatic Cancer): Definition, Biology & Types

A to Z List of Cancer Types

Cleveland Clinic – Metastasis: Definition, Biology & Types

National Cancer Institute – Metastatic Cancer: When Cancer Spreads

American Cancer Society – Understanding Advanced and Metastatic Cancer

NCBI – On the Origin of Cancer Metastasis

The Importance of Caregiver Journaling

Reporting Changes in Condition to Hospice

Free Daily Symptom Tracker

Get Palliative Care – Palliative Care provides support, allowing for treatment

The Caregiver’s Guide to Cancer: Compassionate Advice for Caring for You and Your Loved One (Caregiver’s Guides)

Cancer Caregiving A-to-Z: An At-Home Guide for Patients and Families

Peace in the Face of Cancer

A Handbook of caring for someone with cancer: Instructions for the Support Person or Caregiver Helping a Loved One Survive Cancer

Co-Surviving Cancer: The Guide for Caregivers, Family Members and Friends of Adults Living with Cancer

Things I Wish I’d Known: Cancer Caregivers Speak Out

The National Academy of Elder Law Attorneys (NAELA) is dedicated to improving the quality of legal services provided to older adults and people with disabilities

Articles on Advance Directives

Eldercare Locator: a nationwide service that connects older Americans and their caregivers with trustworthy local support resources

Find the Long-Term Care Ombudsman Program in Your State

Patients Voices Matter Foundation – Empowering Patients, Transforming Lives

Independent Patient Advocate – Independent, non-clinical patient advocacy nationwide. Health Navigation, SSDI Application & Appeals, and Whole Health Advocacy. 100% remote. No insurance accepted.

Natural Death With Dignity: Protecting Your Right To Refuse Medical Treatment

Beyond the Living Will: Creating Effective Advance Directives

Make Your Own Medical & Financial Power of Attorney: A Step-By-Step Guide to Making a Power of Attorney

Last things first, just in case… The Practical Guide to Living Wills and Durable Powers of Attorney for Health Care

Death and Dying: A Good Exit Plan

Free Daily Symptom Tracker

Free Caregiver and Dementia Training Videos

CaringInfo – Caregiver support and much more!

The Hospice Care Plan (guide) and The Hospice Care Plan (video series)

Understanding Palliative Care: A Guide to Common Questions and Answers

Bridging the Gap: Palliative Care’s Role in Supporting Rare Disease Patients

Comprehensive Guide to Financial Assistance for Hospice and Palliative Care Patients

Surviving Caregiving with Dignity, Love, and Kindness

Caregivers.com | Simplifying the Search for In-Home Care

Geri-Gadgets – Washable, sensory tools that calm, focus, and connect—at any age, in any setting

Healing Through Grief and Loss: A Christian Journey of Integration and Recovery

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Caregiver Support Book Series

VSED Support: What Friends and Family Need to Know

My Aging Parent Needs Help!: 7-Step Guide to Caregiving with No Regrets, More Compassion, and Going from Overwhelmed to Organized [Includes Tips for Caregiver Burnout]

Take Back Your Life: A Caregiver’s Guide to Finding Freedom in the Midst of Overwhelm

The Conscious Caregiver: A Mindful Approach to Caring for Your Loved One Without Losing Yourself

Dear Caregiver, It’s Your Life Too: 71 Self-Care Tips To Manage Stress, Avoid Burnout, And Find Joy Again While Caring For A Loved One

Everything Happens for a Reason: And Other Lies I’ve Loved

The Art of Dying

Final Gifts: Understanding the Special Awareness, Needs, and Communications of the Dying

Between Life and Death: A Gospel-Centered Guide to End-of-Life Medical Care

Providing Comfort During the Last Days of Life with Barbara Karnes RN (YouTube Video)

Preparing the patient, family, and caregivers for a “Good Death.”

Velocity of Changes in Condition as an Indicator of Approaching Death (often helpful to answer how soon? or when?)

The Dying Process and the End of Life

The Last Hours of Life

Gone from My Sight: The Dying Experience

The Eleventh Hour: A Caring Guideline for the Hours to Minutes Before Death

By Your Side, A Guide for Caring for the Dying at Home

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