Lymphedema is a chronic condition that affects millions of people worldwide, especially those who have undergone cancer treatment or have other lymphatic disorders. It occurs when the lymphatic system, which drains excess fluid and waste from the tissues, is damaged or blocked. The most common symptom of lymphedema is swelling of the affected limb, which can range from mild to severe. Lymphedema can have a significant impact on the quality of life of patients with serious illnesses, such as cancer, heart failure, or chronic kidney disease. In this article, we will discuss hospice best practices for the management of lymphedema, with a focus on the needs and preferences of terminally ill patients, family members, and caregivers.